• Medical treatments, such as surgery to remove the ovaries
• Cancer treatments, such as chemotherapy or radiation to the pelvic area that damage the ovaries  —  although menopause does not always occur

For women who want to have children, premature menopause can be a source of great distress. Women who still want to become pregnant can talk with their doctors about other ways of having children, such as donor egg programs or adoption.

Having premature menopause puts a woman at more risk for osteoporosis later in her life.  If you have premature menopause, talk to your doctor about whether MHT might be an option for you. We don’t know for sure how MHT might affect younger women. But some researchers think that for these younger women, the risks of MHT use are likely to be smaller and the benefits greater than those in older women who begin MHT at or beyond the typical age of menopause.

Source: Office on Women’s Health in the U.S. Department of Health and Human Services.

However, with certain types of premature menopause, these signs may not be enough for a diagnosis. A blood test that measures follicle-stimulating hormone (FSH) can be done. Your ovaries use this hormone to make estrogen. FSH levels rise when the ovaries stop making estrogen. When FSH levels are higher than normal, you’ve reached menopause. However, your estrogen levels vary daily, so you may need this test more than once to know for sure.

You may also have a test for levels of estradiol (a type of estrogen) and luteinizing hormone (LH). Estradiol levels fall when the ovaries fail. Levels lower than normal are a sign of menopause. LH is a hormone that triggers ovulation. If you test above normal levels, you’ve gone through menopause.

Source: U.S. Department of Health and Human Services.

* Chromosome defects. Defects in the chromosomes can cause premature menopause. For example, women with Turner’s syndrome are born without a second X chromosome or born without part of the chromosome. The ovaries don’t form normally, and early menopause results.
* Genetics. Women with a family history of premature menopause are more likely to have early menopause themselves.
* Autoimmune diseases. The body’s immune system, which normally fights off diseases, mistakenly attacks a part of its own reproductive system. This hurts the ovaries and prevents them from making female hormones. Thyroid disease and rheumatoid arthritis are two diseases in which this can happen.
* Surgery to remove the ovaries. Surgical removal of both ovaries, also called a bilateral oophorectomy [OH-uh-fuh-REK-tuh-mee], puts a woman into menopause right away. She will no longer have periods, and hormones decline rapidly. She may have menopausal symptoms right away, like hot flashes and diminished sexual desire. Women who have a hysterectomy, but have their ovaries left in place, will not have induced menopause because their ovaries will continue to make hormones. But because their uterus is removed, they no longer have their periods and cannot get pregnant. They might have hot flashes since the surgery can sometimes disturb the blood supply to the ovaries. Later on, they might have natural menopause a year or two earlier than expected.
* Chemotherapy or pelvic radiation treatments for cancer. Cancer chemotherapy or pelvic radiation therapy for reproductive system cancers can cause ovarian damage. Women may stop getting their periods, have fertility problems, or lose their fertility. This can happen right away or take several months. With cancer treatment, the chances of going into menopause depend on the type of chemotherapy used, how much was used, and the age of the woman when she gets treatment. The younger a woman is, the less likely she will go into menopause.

Source: U.S. Department of Health and Human Services.